490
Chapter 14
Basement membrane
Movement
of filtrate
Fenestra
Capillary lume
Endothelium
n
Foot
processes
Capsular space
Filtration
slits
Cell processes
Podocyte (visceral layer
of Bowman's capsule)
Cell body
Glomerular
capillary (cut)
Afferent arteriole
Efferent
arteriole
Proximal
tubule
Visceral layer
(podocyte)
Parietal layer
Capillary
Renal corpuscle
Bowman's capsule
Glomerular capillary
(covered by visceral layer)
Filtration
slits
Fenestrae
Juxtaglomerular
apparatus
Juxtaglomerular
cells
Macula densa
Distal
tubule
(c)
(b)
(a)
Substances in the blood are filtered
through capillary fenestrae between
endothelial cells (single layer). The
filtrate then passes across the
basement
membrane and through
slit pores
between the foot processes
(also called pedicels) and enters the
capsular space. From here, the
filtrate is transported to the lumen
of the proximal convoluted tubule.
Podocytes of Bowman’s capsule
surround the capillaries. Filtration slits
between the podocytes allow fluid to
pass into Bowman’s capsule. The
glomerulus is composed of capillary
endothelium that is fenestrated.
Surrounding the endothelial cells is
a basement membrane.
Blood flows into the glomerulus through
the afferent arterioles and leaves the
glomerulus through the efferent
arterioles. The proximal tubule exits
Bowman’s capsule.
a.
b.
c.
Figure 14–3
The renal corpuscle. (a) Anatomy of the renal corpuscle; (b) Inset view of podocytes and capillaries; (c) Transmission electron micrograph of a
glomerular capillary and the glomerular membranes.
Daniel Friend from William Bloom and Don Fawcett, Textbook of Histology, 10th ed., W.B. Saunders Co. (Reproduced by permission of Edward Arnold)
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